RAF Typhoon FGR4s have conducted a mission with France's air force in a joint strike on an underground arms cache in Syria operated by the IS group, as stated by the UK's MoD.
The location, identified by intelligence, was assessed as storing arms and explosives, the statement said, and was located in mountains just above the ancient city of Palmyra in the heart of Syria.
"The RAF jets employed precision-guided Paveway IV munitions to strike a series of entry passages down to the depot... early reports suggest the objective was successfully hit," officials stated.
There was no indication of any civilian casualties in the operation on Saturday evening and every plane involved made a safe return, the defence officials confirmed.
The British jets were supported by a Voyager aerial refuelling aircraft.
IS - also known as Daesh - established extremist governance over significant areas in Iraq and Syria prior to its 2019 collapse.
"This action demonstrates British leadership, and commitment to operate in unison with our partners, to eliminate any re-emergence of IS and their dangerous and violent ideologies in the region," the British Defence Secretary John Healey remarked.
RAF aircraft have conducted surveillance missions over Syria to "forestall any attempted resurgence" of IS after its defeat at the climactic battle in Baghuz in 2019, the MoD reported.
"I want to thank the personnel of the UK armed forces involved in this mission for their expertise and their valour," Healey said. "They were among numerous British personnel deployed over Christmas and New Year. This mission, to eliminate terrorist threats who pose a risk to our safety, highlights how British military are prepared to act, all year round, ensuring Britain's security within its borders and powerful internationally."
During December, the US military conducted what it called a "large-scale strike" on IS targets in the country, following an assault claimed the lives of two American soldiers and a civilian linguist in Palmyra.
The United Nations estimates Daesh still maintains an estimated 5,000 to 7,000 fighters in Syria and Iraq.